Part:BBa_K2081000
Human thyroxine-binding globulin
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.
References:
AUTHORS Ferrara AM, Pappa T, Fu J, Brown CD, Peterson A, Moeller LC, Wyne
K, White KP, Pluzhnikov A, Trubetskoy V, Nobrega M, Weiss RE,
Dumitrescu AM and Refetoff S.
TITLE JOURNAL J. Clin. Endocrinol. Metab. 100 (1), E173-E181 (2015)
AUTHORS Yan Z, Yan H and Ou H. TITLE Human thyroxine binding globulin (TBG) promoter directs efficient
and sustaining transgene expression in liver-specific pattern
JOURNAL Gene 506 (2), 289-294 (2012)
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal XbaI site found at 45
Illegal PstI site found at 340
Illegal PstI site found at 374
Illegal PstI site found at 619 - 12INCOMPATIBLE WITH RFC[12]Illegal PstI site found at 340
Illegal PstI site found at 374
Illegal PstI site found at 619 - 21COMPATIBLE WITH RFC[21]
- 23INCOMPATIBLE WITH RFC[23]Illegal XbaI site found at 45
Illegal PstI site found at 340
Illegal PstI site found at 374
Illegal PstI site found at 619 - 25INCOMPATIBLE WITH RFC[25]Illegal XbaI site found at 45
Illegal PstI site found at 340
Illegal PstI site found at 374
Illegal PstI site found at 619 - 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI.rc site found at 297
Illegal BsaI.rc site found at 399
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